Yes, with a tank arranged around two different schedules
Angelfish can live safely with bristlenose plecos because the two species barely compete for the same hours or the same water. Angelfish are tall, slow midwater fish that feed and display in daylight, while the bristlenose is a compact, armoured bottom dweller that hides in a cave by day and grazes algae, wood, and leftovers after dark. That separation is what makes the pairing dependable in a reasonably sized community tank. The risks that do exist are specific and manageable: food failing to reach the pleco, a cave shortage, and breeding angelfish defending eggs against a fish that blunders into their corner at night.
The bristlenose pleco's real needs in an angelfish tank
A bristlenose pleco needs driftwood, a cave it can claim outright, and food deliberately sunk for it, and an angelfish tank must be set up to provide all three. Bristlenoses rasp on wood as part of their diet, so a bare glass-bottom setup built only around the angels short-changes the pleco. A male bristlenose will defend his cave, usually a hollow log or ceramic shelter, and may fan and guard eggs inside it, which is harmless to angels as long as the cave sits away from the flat leaf or slate where the angels prefer to spawn. One pleco per tank avoids most pleco-on-pleco squabbles entirely.
Feeding both without the angels taking everything
Feed this pairing on two shifts, because angelfish are expert at intercepting food long before it reaches the bottom. Offer the angels their floating or slow-sinking food in the morning, then drop an algae wafer, a piece of blanched courgette, or similar sinking food beside the pleco's cave after lights-out. A well-fed bristlenose grazes the tank calmly, while a chronically underfed one is the pleco most likely to bother other fish. Watch the pleco's belly through the glass occasionally; it should look gently full, not sunken, and the angels should show no interest in the night feeding at all.
The breeding-angelfish exception to watch for
Watch a spawning pair of angelfish closely for the first nights after eggs are laid, because that is the one window where this pairing can turn tense. Angels guard their eggs around the clock and fan them through the night, and a bristlenose wandering in to graze can be driven off hard, or in a small tank, cornered. Keeping the pleco's cave at the opposite end from the angels' chosen spawning surface solves most of it. If a pair spawns repeatedly and the tank is modest, moving the pleco to another aquarium during breeding spells is kinder than letting the same confrontation replay every few weeks.
Keeping the whole household on the same routine
Keep this pairing safe by making the two-shift routine the household habit, not one person's memory, since the night feeding is the step most easily forgotten by a helper. Write down where the pleco's cave sits, what sinking food it gets, and when the angels last spawned, so anyone feeding the tank does the shifts in the right order. Sharing the angels' and pleco's profiles and care notes through KinsLe's Family Sharing means every family member works from the same details, and the pleco's after-dark meal stops depending on a single person remembering it.